Research Interests
The study of structure-function relationships in redox and metalloproteins with particular emphasis on heme proteins. General areas of study include enzyme mechanisms, electron transport, protein-protein interactions, and the role of conformational changes in the activation of enzymes. Techniques used include UV/Vis, Fluorescence, CD and FTIR spectroscopies, as well as standard heterologous protein expression and purification techniques and cell culture techniques. We are currently studying cytochrome P-450 enzymes that are involved in pesticide and herbicide metabolism, and the nitric oxide receptor soluble guanylyl cyclase.
Education
B.S. Physics, University of Florida, 1985
B.S. Biochemistry, University of Illinois at Urbana-Champaign, 1988
Ph.D. Biochemistry, University of Illinois at Urbana-Champaign, 1993
Postdoctoral Training
Department of Pharmaceutical Chemistry, University of California, San Francisco