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I
find the biochemical mechanism underlying the processes of transcription
and gene regulation fascinating. I am particularly interested in transcription
initiation and how a gene that was previously not expressed gets "turned
on". My research interests have focused on the regulation of gene
expression by alternate sigma factors in the soil bacterium Bacillus
subtilis. Recently, I have also become interested in the genetic
determinants that govern behavior in another soil organism, Paenibacillus.
In my laboratory we use state-of-the-art methodology in molecular genetics
and cell biology, as well as classical techniques in microbial physiology.
These techniques allow us to study the environmental and structural
signals that control expression of individual genes involved in adaptation
and particular behaviors in the bacterial cell. Our overall goal is
to elucidate the molecular networks that determine specific bacterial
responses.
L. M-M.
Last modified Sepember 13, 2003
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